Synthesis and Biological Evaluation of 2-Mercaptobenzimidazole Derivatives as Anti-inflammatory Agents
نویسندگان
چکیده
A series of 2-mercaptobenzimidazole derivatives (MB1–MB5) were synthesized by mannich reaction. The purity of synthesized compounds were determined by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The newly synthesized compounds were screened for anti-inflammatory activities on carrageenan induced paw oedema in rats. Compounds MB1 and MB5 showed a significant anti-inflammatory activity when compared with standard drug indomethacin. The other compounds showed promising anti-inflammatory activity.
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